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Objective@#To analyze blood lead levels of children aged 0-14 in Anqing City during 2015 to 2018, to provide basic data for child poisoning prevention and control.@*Methods@#Using questionnaire surveys, physical examination, and laboratory tests to assess blood lead, age, height, weight, personal habits, environmental factors and other relevant information, to analyze associated factors of elevated blood lead levels.@*Results@#From 2015 to 2018, among the 4 406, 4 177, 3 833 and 3 381 children aged 0-14 in the pediatric outpatient, 662, 326, 225, and 56 cases were found with elevated blood lead levels (EBLLs), with the detection rate of 15.02%, 7.80%, 5.87%, and 1.66%, respectively. Detection rate in boys (16.54%, 7.31%, 6.18% and 1.88%) was similar with that of girls (16.04%, 8.51%, 5.42% and 1.33%) ( χ 2= 2.47 , 2.00, 0.99,1.53, P >0.05). Children in any age groups of 0-14 years might have EBLLs, highest in 14-year-old group in the year of 2015 and 2017. Personal behaviors associated with EBLLs included less meat and dairy products consumption, high frequent exposure to soil dust. In contrast, children who wash their hands before meals and wash toys ≥1 time/week were less likely to suffer from EBLLs ( χ 2=13.58，8.91，7.63，9.22， P <0.05). Environmental factors associated with EBLLs included were less than 50 m between the main road with residency, family members smoke, and parents engaged in construction, welding, automobile maintenance and other industries are more likely to have EBLLs, and the difference is statistically significant ( χ 2=4.92，10.63，22.95， P <0.05).@*Conclusion@#The detection rate of EBLLs in Anqing City from 2015 to 2018 depressed by year. Washing hands before meals and cleaning toys frequently could reduce the risk of EBLLs.
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Objective To observe the effect of Xingnao Kaiqiao acupuncture on the clinical efficacy of patients with mild cognitive impairment (MCI) after stroke and to explore its mechanism. Methods A prospective randomized controlled clinical trial method was conducted, 128 patients with MCI after stroke admitted to Department of Acupuncture and Moxibustion of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from September 2015 to May 2017 were enrolled, and they were divided into a control group and an observation group according to the random number table method, 64 cases in each group. The control group took 40 mg of nimodipine, 3 times a day; on the basis of the treatment in control group, the observation group was additionally given acupuncture therapy for arousing the brain and opening the orifices or resuscitation as the interference, the main acupoints applied were renzhong, neiguan (bilateral) and sanyinjiao (bilateral), the scalp points used were mainly baihui joining qianding (GV-21WHO), xinhui (GV-22WHO) joining qianting and benshen (GB-13WHO, bilateral), once a day, 5 times a week; the therapeutic course was 10 weeks in both groups. The differences in scores of Montreal cognitive assessment scale (MoCA), mini-mental state examination (MMSE), and in the levels of serum amyloid A (SAA) andβ-amyloid (Aβ) between the two groups before and 6 and 10 weeks after treatment were compared. Results With the prolongation of therapeutic time, the MoCA and MMSE scores of the two groups were increased significantly after treatment compared with those before treatment, the levels of SAA and Aβ were obviously lower than those before treatment, and the degrees of changes of the above indexes in the observation group were more marked than those in the control group, after treatment for 10 weeks, there were statistical significant differences in MoCA and MMSE scores between the observation and control groups (MoCA score: 25.32±2.54 vs. 22.67±3.17, MMSE score: 28.38±2.74 vs. 24.36±3.27), while after 6 weeks of treatment, the statistical significant differences in SAA and Aβlevels appeared between the two groups [SAA (μg/L): 74.52±25.64 vs. 103.36±27.53, Aβ (ng/L): 95.32±25.64 vs. 127.27±29.73, both P ＜ 0.05], and the situation persisted to 10 weeks after treatment [SAA (μg/L): 57.36±18.24 vs. 84.37±25.56, Aβ (ng/L): 55.47±21.36 vs. 92.74±23.57, both P ＜ 0.05]. Conclusion Resuscitation acupuncture possibly can inhibit the expression protein levels of serum SAA and Aβto improve the cognitive function of patients with MCI after stroke.
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Objective To investigate the effect of dexmedetomidine on perioperative cardiac function in patients with mild cardiac dysfunction undergoing laparoscopic radical resection of rectal cancer. Methods Sixty patients scheduled with laparoscopic radical resection of rectal cancer with mild heart failure were selected, with New York Heart Association (NYHA) cardiac function gradingⅠtoⅡ, American Association of Anesthesiologists (ASA) grading Ⅱ to Ⅲ, and age from 63 to 72 years. The patients were divided into dexmedetomidine group (group D) and control group (group C) according to the random digits table method with 30 cases each. At the beginning of induction, the patients in group D were given intravenous infusion a loading dose of dexmedetomidine at 0.5 μg/kg for more than 10 min. Then continuous intravenous infusion of dexmedetomidine was given at 0.3 μg/(kg·h) for 60 min. The patients in group C were given 0.9% sodium chloride with the same method. The small vessel resistance (SVR), left ventricular end-diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), cardiac output (CO) and myocardial working index (Tei index) before induction (T0) and after administration of 20 min (T1), 40 min (T2), 60 min (T3) were measured by color Doppler ultrasound, and the heart rate (HR) and mean arterial pressure (MAP) were recorded at the same times. The time from the end of operation to extubation and incidences of agitation during recovery period were recorded. Results The T1to T3SVR in group D were significantly lower than those of T0: (883 ± 30), (827 ± 36) and (804 ± 38) dyn·s·cm-5vs. (1 075 ± 37) dyn·s·cm-5, and there were statistical differences (P＜0.05); compared with those in group C, the T1 to T3 SVR in group D were significantly lower, and there were statistical differences (P＜0.05). In group D, there were no statistical differences in CO between T1to T3 and T0(P＞0.05); compared with those in group D, the T1 to T3 CO in group C were significantly lower: (3.4 ± 0.6) L/min vs. (4.4 ± 1.0) L/min, (3.2 ± 0.7) L/min vs. (4.3 ± 0.8) L/min and (3.3 ± 0.9) L/min vs. (4.4 ± 0.9) L/min, and there were statistical differences (P＜0.05). In group D, there were no statistical differences in LVEF between T1to T3 and T0(P＞0.05); compared with those in group D, the T1to T2 LVEF in group C were significantly lower, and there were statistical differences (P＜0.05). In group D, there were no statistical differences in Tei index between T1 to T3 and T0(P＞0.05); compared with group D, the T1 to T2 Tei index in group C were significantly higher, and there were statistical differences (P＜0.05). There were no statistical differences in LVEDV after intra-group and inter-group comparison (P＞0.05). In group D, the T1 to T3 HR were significantly lower than T0: (68.1 ± 12.8), (67.3 ± 11.9) and (65.4 ± 11.7) times/min vs. (88.2 ± 15.1) times/min, and there were statistical differences (P＜0.05); compared with those in group C, the T1 to T3 HR in group were significantly slower. In group D, the T1 MAP significantly increased, significantly higher than those in T0 and in group C (P＜0.05). There was no statistical difference in the time from the end of operation to extubation between 2 groups (P＞0.05). The incidence of agitation during recovery period in group D was significantly lower than that in group C. Conclusions Dexmedetomidine can effectively promote the perioperative cardiac function recovery in patients with cardiac dysfunction undergoing laparoscopic radical resection of rectal cancer, suggesting that it has a certain myocardial protection effect.
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Objective To observe clinical effect of self-made xiaozhongsanjie decoction combined with levothyroxine sodium tablets in treatment of thyroid nodule.Methods From July 2013 to July 2014, 52 cases of thyroid nodule patients were randomly divided into two groups: control group( n=25)and study group(n=27).The control group were received levothyroxine sodium tablets, while the study group were given self-made xiaozhongsanjie decoction on the basis of control group.Both groups were treated for 24 weeks.The changes of thyroid stimulating hormone ( TSH ) , serum free triiodothyronine (FT3), serum free tetraiodothyronine (FT4) levels, and the thyroid nodule size of two groups before and after treatment were recorded and compared.ResuIts After 24 weeks’ treatment, the thyroid nodule size of both groups reduced, and the descending range of study group was much larger than that of control group (P<0.05).The TSH levels of both groups descended, and the descending range of study group was much larger than control group (P<0.05).While the FT4 levels all increased in both groups, and the ascending range of study group was much larger than control group (P<0.05).And the total effective rate of study group was 77.78%, which was significantly higher than control group (48.00%, P<0.05). ConcIusion The therapy of self-made xiaozhongsanjie decoction combined with levothyroxine sodium tablets in treatment of thyroid nodule could control or reduce the thyroid nodule size effectively.
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AIM: To investigate the vasorelaxant effect and mechanism of EtOAc extract from Chrysanthemum morifolium Ramat (CME). METHODS: The effects of CME on the contraction of rat thoracic a orta were examined. RESULTS: CME caused concentration-dependent relaxation of aorta rings precontricted with phenylephrine and K+. The effect in endothelium-intac t aorta was more effective than that in endothelium-deduced aorta. NG-nitro-L- arginine methylester, methylene blue and glibenclamide attenuated the effect of C ME significantly. However, indomethacin, propranolol, tetraethylammonium, BaCl 2, 4-aminopyridine and 5-hydroxydecanoate did not affect CME effect. The effect of SKF-525A combined with L-NAME had no obvious difference with that of L-NAME o n CME-induced relaxation. NOS activity in aorta was increased markedly by CME in vitro. CME did not reduced the contraction elicited by PE in Ca 2+-f ree medium, but reduced the contraction induced by PE in K+-free solution or C a 2+ free following input Ca 2+. CONCLUSION: CME induces both endothelium-dependent and independe nt relaxation. NO and cGMP are likely involved in the endothelium-dependent rela xation, inhibition of voltage-dependent or receptor-operate Ca 2+ channel a nd activation of ATP-sensitive K+ channel contribute in part to the endotheliu m-independent relaxation by CME.